I have the samme issue with a r7 260x so the problem come from amd.
I have the latest driver, i tried to launch in windows 7 compatibility mod,install directx from june 2010 as I saw in an other topic but the problem is still there.There is a problem with windows 10 x64 and amd graphics card and i don't have integrated chipset so this is unplayable.
I wish a staff member see this and can report that to the dev and i also bought a membership which is useless because my game keep crashing.